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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They also provide a useful method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not be used in lieu for explanation studies.
프라그마틱 환수율 of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which inform the practice and policy decisions. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.